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Journal of Korean Cleft Palate-Craniofacial Association 2005;6(1):1-10.
The Bone Regenerative Effect of Calcium Sulfate- chitosan Complex Powder and Chitosan Microsphere Encapsulating Growth Hormone on Bone Formation in Bone Defect of Rabbits.
Kyung Min Jang, Jong Yeop Kim, Jung Duk Yang, Dong Gul Lee, Ho Yun Chung, Jae Woo Park, Byung Chae Cho, Byung Hun Lee, In San Kim, Dong Sin Lee, Eun Hee Bae
1Department of Plastic Reconstructive Surgery, College of Medicine, Kyngpook National University, Daegu, Korea. bccho@knu.ac.kr
2Department of Biochemistry, College of Medicine, Kyngpook National University, Daegu, Korea.
3Regen Biotech, Seoul, Korea.
This study was carried out on 32 New Zealand white rabbits, each weighing 3-3.5kg. Eight rabbits were allocated into each of four groups. The groups were a control group(I), hyaluronic acid group(II), chitosan microsphere encapsulating growth hormone group(III), calcium sulfate-chitosan powder group(IV). After a 1cm sized ostectomy was made on the tibial body with the periosteum preserved, artificial bone substitutes were implanted. Except group I, 1ml of hyaluronic acid were implanted in group II, 1ml of chitosan microsphere encapsulating growth hormone in group III, 1ml of manufactured calcium sulfate-chitosan complex powder in group IV.


were evaluated using radiographic study every week, bone mineral density test and histologic examination at 2, 4, 6 weeks and three point bending test at 6 weeks after implantation. In the radiographic study, the formation and corticalization of callus were seen similarly in group III, IV and much more and earlier than group I, II. In the bone mineral density test and three point bending test to contralateral normal tibia in 6 weeks, the values in groups III and IV were statistically significantly higher than in group I and II(p<0.05). In histologic examination, group III and IV have more abundant and faster new boner formation than group I and II. In conclusion, calcium sulfate-chitosan complex powder and chitosan microsphere encapsulating growth hormone facilitates the formation of new bone. They will be used effectively as a bone substitute on defected bone in clinical situations.
Keywords: Calcium sulfate-chitosan complex powder; Chitosan microsphere; Growth hormone; Bone defect; Bone regeneration
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