Anthropometric Analysis of Facial Foramina in Korean Population: A Three-Dimensional Computed Tomographic Study

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Abstract

INTRODUCTION

The three major sensory nerves of the face are supraorbital, infraorbital and mental nerve. Originating from the trigeminal ganglion in the skull base, nerve fibers supplying these travel through the facial skeleton and exit via the respective foramen. Hence, the location of each foramen is an important consideration in facial bone fracture, cosmetic surgery, and regional nerve block.

Previously, the location of facial foramina has been studied using dry cadaveric bones [123], photographs of dry bones [4], and radiographs limited to simple X-ray [5]. In this study, we report on anthropometry and morphology of these foramina using three-dimensional computed tomography (3D-CT) data. In order to obtain clinically meaningful data, various anthropometric measurements were compared according to sex and age. In addition, relationships between foramina and dentition were examined for significant association.

METHODS

This retrospective study included all patients who had undergone 3D facial CT studies between January 2008 and March 2014 at a university hospital. Patients were excluded for congenital deformity of the face and for history of a fracture in maxilla, frontal, mandible, or orbital bone. Patients with history of nasal bone fracture or soft-tissue contusion were not excluded.

Two multidetector CT machines were used for facial bone scans (Light Speed Ultra 16 and Discovery CT750 HD, General Electric, Milwaukee, WI, USA). Each image slice was obtained at 0.625-mm thickness, which provides higher axial resolution than the usual image thickness used for 2D scanning (1.25 mm).

Each patient's facial CT reconstruction was loaded into a PACS station.

The largest supraorbital exit on the 3D-CT image was labeled as the foramen/notch and used for subsequent measurements. Distances were measured between supraorbital foramen (SOF) and facial midline (FM), infraorbital foramen (IOF) and FM, IOF and inferior orbital margin (IOM), mental foramen (MF) and FM, MF and inferior mandibular margin (IMM). Each distance was measured in the geometric central of each foramen or notch (Table 1, Fig. 1) [1].

Table 1

Definitions used for anthropometry

Fig. 1

Anthropometric measurements on computed tomography scan. (A) SOF-FM, distance from supraorbital foramen (or notch) to facial midline. (B) IOF-IOM, distance from infraorbital foramen to inferior orbital margin. (C) IOF-FM, distance from infraorbital foramen to facial midline. (D) MF-FM, distance from mental foramen to facial midline. (E) MF-IMM, distance from mental foramen to inferior mandibular margin. a, first premolar; b, second premolar; c, first molar; Position 1, superior (or inferior) to the first premolar; Position 2, between the first and second premolar; Position 3, superior (or inferior) to the second premolar; Position 4, between the second premolar and first molar; Position 5, superior (or inferior) to the first molar; SOF, supraorbital foramen; FM, facial midline; IOF, infraorbital foramen; IOM, inferior orbital margin; MF, mental foramen; IMM, inferior mandibular margin.

Each distances were measured twice, and the average of the two values were used for comparisons. Statistical analyses included cross tabulation, independent T-test, and one-way analysis of variance (SPSS ver. 22.0, SPSS Inc., Armonk, NY, USA).

RESULTS

The retrospective review identified 137 patients who met the inclusion criteria (76 male and 61 female). The mean age was 36.5 years (range, 18 to 78 years) (Table 2).

Table 2

Demographic information

Supraorbital exit morphology consisted of 62% foramen type and 38% notch type. For IOF position, position 3 accounted for 38% (104/274), the most frequent position, position 5 was 28.5% (78/274), position 4 was 16.8% (46/274), position 2 was 9.9% (27/274) and position 1 was 6.9% (19/274) in descending order. For MF position, position 3 accounted for 40.1% (110/274), the most frequent position, position 5 was 30.7% (84/274), position 4 was 21.5% (59/274), position 2 was 5.5% (15/274) and position 1 was 2.2% (6/274) in descending order (Fig. 2).

Fig. 2

The position of IOF and MF. The most frequent position was position 3 (superior (or inferior) to the second premolar). IOF, infraorbital foramen; MF, mental foramen.

The average distances of SOF-FM, IOF-FM, IOF-IOM, MF-FM, and MF-IMM were 33.7 mm, 37.1 mm, 13.4 mm, 33.7 mm, and 21.0 mm; respectively (Table 3).

Table 3

Foraminal anthropometry

Between male and female groups, most foraminal positions were not statistically different. One exception was that of the distance between mental foramen and inferior margin of the mandible (MF-IMM). In men, the mean MF-IMM distance was 21.7 mm whereas this same value was 20.1 mm in females (p<0.01). This suggests a small but significant difference in the relationship between the mental foramen to the inferior edge of the mandible, which places the mental foramen slightly further away from the mandibular edge.

Regarding the relationship between age and foraminal positions, all three of the foramina was further away from midline (FM) with age (p<0.05). Additionally, a the distance between infraorbital foramen (IOF) and infraorbital margin (IOM) decreased with age (p<0.001). The mental foramen and inferior mandibular margin (MF-IMM) distance became narrower with increasing age, but this trend was not statistically significant (p=0.356) (Table 4, Fig. 3).

Table 4

Anthropometry according to age

Fig. 3

Changes in the measured value in accordance with age. Distances between SOF, IOF, MF, and FM became wider as age increased (p<0.05). On the other hand, IOF-IOM distance became narrower as age increased (p<0.001). MF-IMM distance became narrower as age increased, but not significantly (p=0.356). SOF, supraorbital foramen; FM, facial midline; IOF, infraorbital foramen; MF, mental foramen; IOM, inferior orbital margin; IMM, inferior mandibular margin.

Between the left and right sides, the IOF position was significantly different (p=0.014). On right side, the IOF was most frequently in position 5 (33.6%), while position 3 was the most frequent on left side (45.3%).

DISCUSSION

Various studies have looked at anatomic positions and morphology of facial foramina of sensory nerves [12345]. In terms of supraorbital exit morphology, Chung et al. [4] reported that supraorbital foramina (28.9%) were less frequently observed than supraorbital notches (69.9%). Subsequent to this, Saylam et al. [6] reported similar frequencies between foramen and notch morphology (26.6% and 71.6%, respectively). Gupta [1] reported the morphological frequencies of SOF and SON as 45.6% and 54.4%, respectively. In our study, however, foramen type morphology was more frequent (62%) to notch morphology (38%).

Gupta [1] using dry skull (North-west Indian) reported position 3 (superior or inferior to second premolar) to be the highest frequency, accounting for more than 50% of all IOF and MF positions. Similarly, we found that position 3 was the most frequent position for IOF and MF, albeit to a lesser degree (38% and 40.1%, respectively).

Studies on facial skeletal aging have concentrated on posterior displacement of the maxilla and shifting of the lateral and inferior orbital rim, creating a larger orbital aperture with aging. Additional studies on the lower face have revealed decreasing mandible length and height with age [78910111213]. In our study, older patients demonstrated supraorbital and infraorbital foramen which were significantly further away from the midline, which suggested lateral translation of frontal and maxillary bones with aging. Also, the decreased distance between the infraorbital margin and infraorbital foramen also corresponds with the theory that the orbital aperture widens inferiorly as well as laterally. Lateral translation was also observed for mental foramen (increased MF-FM distance), which was a result that contrasts previous findings of decreasing mandibular length with aging.

Studies on foramina position and morphology is helpful in operations such as brow-lift, blepharoplasty, and genioplasty as this information decreases the chance of inadvertent injury to the supraorbital, infraorbital, and mental nerves [14]. Also, such anthropometric data can be useful in facial bone surgery or skull base surgery. More specifically, position of the infraorbital foramen relative to midline and to lower orbital margin is important for prevent injury to the infraorbital neurovascular bundle [15]. Our study results can be helpful in Korean patients and, more generally, East Asian patients.

It is important to note that specific differences of these foramina, depending on sex and age of the patient, and this information should inform operating surgeons as they prepare for injection of local anesthetic or for periosteal dissection around the foramina.

The limitation of this study is that it did not consider variables which could affect the anthropometry, such as face size or skull size of the patient.

In addition, in this paper we have used pearson coefficient correlation analysis in accordance with age. Considering the characteristic feature of pearson coefficient, p-value may lack clinical significance despite existing statistic significance between variables.

Future studies will be needed for validation of these results.

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