DISCUSSION
Cutaneous cysts can be divided into three types according to their morphology and specific pattern of differentiation: (1) stratified squamous epithelium; (2) non-stratified squamous epithelium; and (3) absence of epithelium [
5]. Epidermoid cysts belong to the first category and are known to account for 79% of all cutaneous cysts [
3].
Epidermoid cysts are relatively rare, slow-growing benign cysts [
6]. They can be congenital or the result of skin damage. They are lined by an epithelium that resembles the infundibulum of the hair follicle and expresses the same cytokeratin profile [
1]. They appear to be caused by epithelial invagination into the tissue; alternatively, the eccrine duct can form a cyst on an area that lacks hair follicles [
1]. In addition, they can occur in genetic disorders such as Gorlin syndrome (also known as nevoid basal cell carcinoma syndrome) or Garber syndrome [
1,
3]. When epidermoid cysts occur, the diseases to be differentially diagnosed include steatocystomas, pilar cysts, lipomas, dermoid cysts, furuncles, branchial cleft cysts, milia, calcinosis cutis, pachyonychia congenita, and melanomas, amongst others [
1,
5].
Cutaneous cysts reportedly occur more frequently in men than women; the rate has been variously reported. For example, Dutta et al. [
4] reported a male-to-female ratio of 4.6:1 and Jham et al. [
7] reported a ratio of 3:1. In Korea, Han and Kim [
8] reported a ratio of 1.8:1 and Heo and Oh [
9] reported a ratio of 2.8:1. In this study, we found that the rate of occurrence in women was higher than in these previous reports, at a male-to-female ratio of 1.5:1. Given that epidermoid cyst removal is usually performed for cosmetic reasons, the increase in social activities of women between the time periods captured by previous studies and those captured by our study, may have driven the increased occurrence in women.
In this study the number of surgeries per year did not differ greatly between 2001 and 2015, but has risen sharply since 2015. The increase in surgery may be due to several factors. First, most recent patients have been issued medical certificates for insurance company claims which may reflect the increasing number of subscribers of loss insurance that can guarantee a reimbursement for the amount incurred for medical expenses. Second, there has been an increased interest in beauty.
Cutaneous cysts usually occur after puberty, and Han and Kim [
8] reported most cases among patients in their 20s, while Heo and Oh [
9] reported the most cases among patients in their 30s and 40s. In this study, epidermoid cysts were most common among patients in their 40s and 50s, followed consecutively by those in their 20s, 30s, and 60s. This result is understandable, since those in their 40s and 50s are the most active generation in terms of social activities. It is, however, unusual that the surgery was performed at a relatively high rate among patients in their 60s and older, suggesting that the extent of care regarding appearance in life after retirement is gradually increasing, and that it is financially supported to the extent that surgery can be performed.
Epidermoid cysts are slow-growing, and are usually only found after reaching a certain size [
6,
10]. During physical examination, epidermoid cysts present as a painless, movable mass on the dermis or subcutaneous layer, with a keratin-filled orifice–the punctum–on the surface (
Fig. 2). A noticeable characteristic is that the cyst can communicate with the skin surface through the punctum [
5], and the punctum is useful for differential diagnosis from similar cysts such as dermoid cysts.
Diagnosis is performed via a number of techniques including physical examination, radiological examination, and biopsy. Radiological studies include sonography, computed tomography, and magnetic resonance imaging, and in this study we used sonography if necessary. In a sonography image, the epidermoid cyst appears as a heterogenous low echogenicity area with a slight increase in sound transmission (
Fig. 3) [
11]. Histologically, epidermoid cysts are lined by a stratified squamous epithelium resembling the epidermis and include a granular layer and keratin lamellae in the lumen (
Fig. 4).
When considering incidence according to lesion location, Choi et al. [
12] reported 23 cases on the trunk (34.3%), nine cases on the face (12.6%), eight cases on the neck (12.0%), six cases on the buttocks (9.0%), five cases on the leg (7.5%), four cases on the scalp (6.0%), and three cases on the foot (4.5%). Han and Kim [
8] reported 66 cases on the trunk (21.9%), 63 cases on the face (20.9%), 42 cases on the neck (13.9%), and 20 cases on the scalp (6.6%). Sung et al. [
13] reported 35 cases on the trunk, 23 cases on the face, 20 cases on lower extremities, nine cases on upper extremities, five cases on the scalp, and one case on the whole body. The figures we report in this study demonstrate an overwhelming majority of cases on the face, in contrast to previous studies that generally report the most frequent occurrence to be on the trunk. This is also thought to be driven by the growing interest in beauty and the flourishing economy in South Korea and will require continuous follow-up observation.
Underlying diseases were, in descending order of frequency, hypertension, diabetes mellitus, and hyperlipidemia. Although these did not appear to be related to the occurrence of epidermoid cysts, the relationship needs further investigation through long-term and large-scale research. Squamous cell carcinoma and basal cell carcinoma have previously been reported in rare cases of malignancy [
5] but carcinoma was not detected in this study [
5].
Treatment may be total excision; in some cases, the minimal excision technique presented by Zuber was used [
14]. Complications such as inflammation and wound dehiscence have also been reported previously [
1] but they did not occur in this study. In this 20-year retrospective study, we report that the incidence of epidermoid cysts among women, as measured by the number of surgeries at our hospital, has increased compared to previous reports. We also report that the incidence of epidermoid cysts on the face has increased compared to previous reports.