Staged reconstruction of a chronically infected large skull defect using free tissue transfer and a patient-specific polyetheretherketone implant

Article information

Arch Craniofac Surg. 2020;21(5):309-314

Publication date (electronic) : 2020 October 20

doi : https://doi.org/10.7181/acfs.2020.00311

Seung Jin Moon^1,2, Hong Bae Jeon^1,2, Eui Hyun Kim³, Dae Hyun Lew^1,2, Yong Oock Kim^1,2, Jong Won Hong^,1,2

¹Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea

²Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea

³Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea

Correspondence: Jong Won Hong Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea E-mail: saturn@yuhs.ac

This study was supported by a faculty research grant of Yonsei University College of Medicine (grant No. 6-2016-0147).

Received 2020 July 7; Revised 2020 August 31; Accepted 2020 October 14.

Abstract

INTRODUCTION

Composite scalp and cranial defects are not uncommon problems, especially in cases with infection or radiation. The cranial defects can cause problems in brain protection, aesthetic appearance, cerebral hydrodynamics, and neurologic function, thereby require cranioplasties [1,2]. Also, proper soft tissue coverage over the cranioplasty material is mandatory for a successful reconstruction. Despite many options for skull and scalp reconstruction, determining a cranioplasty material and soft tissue coverage method is challenging for a large complex defect on scalp and cranium [3]. A non-vascularized bone flap is inappropriate to be grafted in unhealthy soft tissue. A chimeric free flap, such as vascularized scapular bone and latissimus dorsi (LD) flap, can be utilized to reconstruct composite defects and has a high ability to resist infection and bone resorption [4]. However, since the available quantity of bone in a chimeric flap is limited, an alloplastic implant would be reasonable for a sizable defect. Furthermore, free soft tissue transfer for scalp reconstruction is necessary when defects are extensive that local or regional options are unavailable.

In alloplastic cranioplasty, one of the main complications is infection [5]. Therefore, when reconstructing composite defects with a history of infection, decisions on methods and timing of reconstruction should be made carefully. In this report, we describe a patient who underwent scalp reconstruction with free vascularized flap and delayed cranioplasty using a patient-specific polyetheretherketone (PEEK) implant for a massive cranial defect with a chronically infected wound which was not improved by repeated surgical debridement and antibiotic treatment for 3 months.

CASE REPORT

A 31-year-old male patient visited Severance Hospital for a scalp and skull defect and uncontrolled wound infection (Fig. 1). Two years earlier, the patient had a decompressive craniectomy for traumatic subarachnoid hemorrhage and intracranial hemorrhage due to a motorcycle accident. Subsequently, drainage and insertion of an external ventricular drain for a subdural abscess were performed. Cranioplasty with cryopreserved autologous bone graft was performed 6 months after the trauma. The patient continuously scratched the surgical site with his hand, which resulted in a subsequent scalp wound and infection. The infected bone graft was removed, and the soft tissue defect was repaired with local flap advancement. However, surgical site infection and scalp defect recurred, and it was not improved with continuous wound care, debridement, and antibiotic treatment for 3 months. The patient was admitted to our hospital for infection control and reconstruction. At the time of the admission, his level of consciousness was alert, but he was quadriplegic and showed a low score (19) on the Mini-Mental State Examination. Previously grafted artificial dura was exposed, and Klebsiella pneumonia, methicillin-resistant Staphylococcus aureus (MRSA), and Acinetobacter baumannii were identified in wound cultures.

Fig. 1.

Preoperative photograph of the skull and scalp defect on the right temporo-parietal area. The artificial dura is exposed. Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii were identified in the wound culture.

Since resolution of the infection was a priority, removal of the exposed artificial dura, extensive debridement including infected bone, massive irrigation, duroplasty with Biodesign dural graft (Cook Medical, Bloomington, IN, USA), and defect coverage with LD myocutaneous free flap and split-thickness skin graft were performed (Fig. 2). Considering the high risk of infection, cranioplasty was planned to be performed at least 1 year after confirming resolution of the infection. The size of the LD flap and its skin paddle was 17×19 cm² and 7×19 cm², respectively. The facial artery and vein on the right cheek were prepared as donor vessels, and anastomosis was performed.

Fig. 2.

(A) Intraoperative photograph after debridement and duroplasty. (B) The defect is covered with a latissimus dorsi myocutaneous free flap and split-thickness skin graft.

Nine days after the surgery, the skin graft became unstable, and necrosis of the flap was observed. MRSA and A. baumannii were reported from pus-like fluid accumulated under the flap. A detachment of the LD flap, debridement, duroplasty, and 17×19 cm² sized anterolateral thigh (ALT) myocutaneous free flap transfer were performed, and the ALT flap was taken successfully. Vessel anastomosis was performed proximal to the same recipient vessels.

The reconstructed area initially had a convex shape due to a sufficient volume of the ALT flap. Six months after the second microsurgical surgery, flap sinking on the cranial defect area was observed (Fig. 3). However, since there was no evidence of neurologic deterioration, we decided to perform the cranial reconstruction following the originally planned schedule.

Fig. 3.

Depression of the anterolateral thigh flap on the temporoparietal cranial defect.

The cranioplasty was done with a patient-specific PEEK implant (Depuy Synthes; Oberdorf, Switzerland) at 1 year and 3 months form the second microsurgical reconstruction. The implant was designed with less curvature than of the contralateral side because we worried that the pedicle vessel would be damaged if the flap was stretched out too much. Furthermore, the implant was designed to match the irregular thickness of the reconstructed scalp flap observed in the planning computed tomography (CT) scan to achieve a smooth and concave head shape considering (Fig. 4). During surgery, previously grafted ALT flap was successfully separated from the dura with careful protection of the flap pedicle. Pedicle identification and flap monitoring using Doppler were performed periodically. After the skull defect was fully exposed, bone margin debridement, dura tenting suture, and implant fixation with titanium hardware were performed (Fig. 5). Finally, the flap was sutured to the scalp flap in its original position with minimal tension. The depressed external contour was improved after the cranioplasty and the postoperative CT scan identified sufficient brain re-expansion and normalization of ventricle sizes (Fig. 6). There was no evidence of complications such as infection, wound dehiscence, or fluid collection over the 1-year follow-up period (Fig. 7).

Fig. 4.

Planning computed tomography image and design of the patient-specific implant (PSI). Shifting of brain parenchyma and decrease in ventricular size was observed. The irregular thickness of the reconstructed scalp flap was considered to achieve a smooth and concave head shape after cranioplasty.

Fig. 5.

Intraoperative photograph after dura tenting suture and fixation of the patient-specific polyetheretherketone implant.

Fig. 6.

Computed tomography scan at 1 week after the cranioplasty.

Fig. 7.

Photograph of the patient at the 1-year follow-up.

DISCUSSION

When reconstructing complex scalp and cranial defects, careful consideration must be given to the selection of cranioplasty materials, soft tissue coverage methods, and timing of surgeries, regarding histories of prior surgery, infection, and adjuvant therapy on the defect area. Simultaneous reconstruction of both scalp and cranium may reduce a burden of repetitive general anesthesia and show quicker recovery. However, single-stage reconstruction may not be feasible in the cases of sizable and currently infected composite cranial defects which need wound salvage quickly.

In the present case, before the first microsurgical reconstruction, infection on the extensive defect was not improved with continuous intravenous antibiotics and surgical debridement, and exposure of artificial dura was observed. A LD flap was initially selected for scalp reconstruction because muscle flaps are relatively resistant to infection and can cover large areas with minimal donor site morbidity [6]. However, due to the flap failure, the second free flap transfer was performed with the ALT flap, which was harvested as a myocutaneous flap for the same reason as the LD flap.

Recent advances in computer-assisted design and computerassisted manufacturing technologies have enabled patient-specific implants based on titanium, poly-methyl-methacrylate (PMMA), and PEEK to reduce surgical time and pursue better cosmetic results [7,8]. A PEEK-based implant has several advantages over other cranioplasty materials. It is lighter than a titanium implant of the same volume, resistant to heat and radiation, and radiolucent. In addition, PEEK has stiffness and strength similar to bones, so it can provide sufficient brain protection and be handled similarly to bones [9]. For example, modification of PEEK implants with burring during surgeries and use of conventional fixation hardware are possible. In a meta-analysis comparing with titanium mesh and autologous bone graft, PEEK-based implants showed a similar risk of complications, including infection, hematoma, exposure, and failure of reconstruction [10]. However, to our knowledge, there is no paper analyzing long-term results of more than 5 years after cranioplasty with a patient-specific PEEK implant. Infection may appear even after 1 year of alloplastic cranioplasty, and the average time interval between cranioplasty with titanium mesh and implant exposure occurrence was reported as 33.6 months [11]. Although no infection or exposure of the patient-specific PEEK implant was observed in this study, 1-year follow-up period after the cranioplasty may be not enough to confirm the safety of the implant. A large sample study with long-term follow-up is needed to elucidate effectiveness and reliability of PEEK implants.

There are several points to consider when designing a patient-specific implant. Since the skull has a round shape, the implant is usually designed in a convex shape, which is also intended to make space for brain parenchyma expansion [12]. However, the brain may not be expanded sufficiently in cases with histories of repeated surgeries or infection, which make fibrotic tissue on the defect area. Therefore, the final head shape on the defect was designed to be less convex than that on the contralateral side. Besides, it was necessary to prevent excessive tension on the previously grafted ALT free flap after implant reconstruction.

After implant reconstruction, brain expansion occurred sufficiently, and no dead-space was observed in the follow-up CT scan. Despite the gross improvement of the scalp depression, there was a mild irregularity of the final scalp contour. We expected that irregular thickness of the flap on the planning CT scan would be maintained after the cranioplasty. Nevertheless, soft tissue thickness on the defect area was nearly even on the postoperative CT scan, thereby revealing the implant’s curvature.

Infection is a significant complication when using allografts and can lead to reconstruction failure. Manson et al. [13] reported that the ideal time to reconstruct a skull defect of a frontal area with an alloplastic material is more than 1 year from the previous injury or infection. Kwiecien et al. [14] investigated the relationship between the timing of alloplastic cranioplasty after osteomyelitis and reinfection, finding that the reinfection rate was reduced by 10% for each month of cranioplasty delayed after removal of the infected bone. Although some reports demonstrated that early cranioplasty is feasible for patients with osteomyelitis [15,16], we decided to perform cranioplasty with the PEEK implant after confirming no evidence of infection for at least 1 year since the patient had the history of repeated infection for 2 years.

In conclusion, the present study suggests that early soft tissue coverage with free flap and delayed cranioplasty with a customized PEEK implant is an appropriate option to reconstruct extensive scalp and cranial defects with chronically infected wounds. Since a sinking skin flap on a skull defect may cause a shift of brain parenchyma, changes in cerebrospinal fluid hydrodynamics, and rarely, neurological dysfunction [17,18], regular follow-up with brain CT and neurological examination is necessary during the time between the soft tissue coverage and the cranioplasty.

Article information Continued